Cognitive Longevity, Through Sound.
800 Million People Struggling to Hear in Noisy Places This affects one third of people at the age of 40, and half by age 65. Untreated hearing loss is the #1 modifiable risk factor for dementia. This outcome likely stems from the brain being deprived of a sensory input, and the most common reaction to this loss: social isolation. We're developing the first-in-class therapy that reverses the neurological root cause of this hearing deficit.
Hearing aids don’t solve all hearing loss
When ears have a volume problem, we call that peripheral hearing loss. Hearing aids handle it. When the brain can no longer separate a voice from the noise around it, that's central hearing loss. No treatment exists for this “cocktail party effect”. Patients withdraw from conversations, then from social life, and their dementia risk doubles.
Meet LOOT: the first therapy targeting the neurological root cause
Localized Oligodendrocyte Optimization Therapy is a 30-day combination of targeted audio stimulation with a repurposed, previously FDA-approved,oral medication. Together, they prompt the brain to repair the myelin sheaths in the auditory brainstem that have worn down with age.
Reduced
Optimized
Seven years of research. One causal mechanism. ~90% reversal in animals.
$7M NIH grant funds the demyelination hypothesis
Neurosurgical animal studies
Аnd computational models confirm the root cause; treatment shows a 1.5 effect size in preclinical experiments
First patent filed
Сompany formed, two additional NIH grants scored 3rd & 8th percentile, FDA clears IND 175835
FDA Phase II clinical trial begins
Enrollment at CU Anschutz ; $6M NIH grant for basic science; second patent filed
Founded by the team who discovered the mechanism
Parley spun out of the Klug Lab at the University of Colorado Anschutz Medical Campus - the #5 medical research university in the world and home to 15% of all active U.S. clinical trials. The founding team has decades of auditory brainstem and biotech operating expertise.
Are you losing conversations in noisy rooms?
Phase II volunteer enrollment is open at CU Anschutz Medical Campus.
